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The SCIFF‐Derived Ranthipeptides Participate in Quorum Sensing in Solventogenic Clostridia
Author(s) -
Chen Yunliang,
Yang Yunpeng,
Ji Xinjian,
Zhao Ran,
Li Guoquan,
Gu Yang,
Shi Aiping,
Jiang Weihong,
Zhang Qi
Publication year - 2020
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.202000136
Subject(s) - clostridia , quorum sensing , biochemistry , clostridium , biology , peptide , chemistry , computational biology , bacteria , genetics , gene , virulence
Ranthipeptides, defined as radical non‐α thioether‐containing peptides, are a newly emerging class of natural products belonging to the ribosomally synthesized and post‐translationally modified peptide (RiPP) superfamily. Ranthipeptides are shown to be widespread in the bacterial kingdom, whereas heretofore their biological functions remain completely elusive. In this work, putative ranthipeptides are investigated from two solventogenic clostridia, Clostridium beijerinckii and Clostridium ljungdahlii , which are derived from the so‐called six Cys in forty‐five residues (SCIFF) family of precursor peptides. A series of analysis show that these two ranthipeptides participate in quorum sensing and controlling cellular metabolism. These results highlight the diverse biological functions of the ever‐increasing family of RiPP natural products and showcase the potential to engineer industrially interesting organisms by manipulating their RiPP biosynthetic pathways.