Cover Picture: Biotechnology Journal 8/2019 | Zendy

Duarte Sofia O. D. | Zendy; Martins Maria C. | Zendy; Andrade Sílvia M. | Zendy; Prazeres Duarte M. F. | Zendy; Monteiro Gabriel A. | Zendy

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Cover Picture: Biotechnology Journal 8/2019

Author(s) -

Duarte Sofia O. D.,

Martins Maria C.,

Andrade Sílvia M.,

Prazeres Duarte M. F.,

Monteiro Gabriel A.

Publication year - 2019

Publication title -

biotechnology journal

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.144

H-Index - 84

eISSN - 1860-7314

pISSN - 1860-6768

DOI - 10.1002/biot.201970081

Subject(s) - plasmid , lactococcus lactis , escherichia coli , biology , microbiology and biotechnology , genetics , dna , bacteria , gene , lactic acid

Lactococcus lactis is a safer and cost‐effective alternative to the lipopolysaccharide‐producing Escherichia coli as a cell factory for pharmaceutical‐grade plasmid production, but the available plasmids are not able to replicate with a high copy number in L. lactis . The pTRKH3‐b mutant engineered in the present work achieved 215(±38) copies of plasmid per chromosome, a 3.5 fold increase from the non‐modified pTRKH3 (62±5). This is reported by Sofia O. D. Duarte, Maria C. Martins, Sílvia M. Andrade, Duarte M. F. Prazeres, and Gabriel A. Monteiro in article 1800587 .

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