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Cover Picture: Biotechnology Journal 3/2018
Publication year - 2018
Publication title -
biotechnology journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201870031
Subject(s) - chinese hamster ovary cell , cover (algebra) , synthetic biology , computer science , microbiology and biotechnology , computational biology , world wide web , biology , genetics , engineering , cell culture , mechanical engineering
In the last 30 years Chinese hamster ovary (CHO) cells have been developed into highly efficient cell factories. In this time optimization evolved from random approaches and screening towards systems and synthetic biology strategies. Rational modifications on a genomic, transcriptomic and glycomic level, enhancement of signaling pathways or optimization of promoter design increased cell specific productivity and product quality. Cover page prepared by Nadiya Romanova and Thomas Noll, authors of the article “Engineered and Natural Promoters and Chromatin‐Modifying Elements for Recombinant Protein Expression in CHO Cells”, article number 1700232 .