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Continuous Virus Inactivation: How to Generate a Plug Flow
Author(s) -
Jungbauer Alois
Publication year - 2019
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201800278
Subject(s) - continuous flow , computer science , residence time (fluid dynamics) , process (computing) , process engineering , biochemical engineering , plug flow , residence time distribution , continuous production , flow (mathematics) , nanotechnology , environmental science , materials science , engineering , physics , mechanics , geotechnical engineering , operating system , environmental engineering
To realize continuous integrated manufacturing of biopharmaceuticals, all steps of production have to be operated in a continuous mode. Virus inactivation is a crucial step in this process, and due to standard procedures and a fixed residence time, it is particularly challenging to realize. Two articles in this issue present possible solutions to this problem.