Premium
Cover Picture: Biotechnology Journal 9/2017
Publication year - 2017
Publication title -
biotechnology journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201770091
Subject(s) - art , cover (algebra) , computer science , library science , art history , world wide web , medicine , chemistry , engineering , mechanical engineering
A new implantable 3D printed device has been fabricated with polylactic acid (PLA) to house pancreatic islets graft. The structure of the device and the addition of an angiogenic matrix within the scaffold have been designed to permit a rapid and mature vasculature to the encapsulation system before cell implantation. Human pancreatic islet loading resulted in a sustained insulin secretion for months. The figure shows the 3D printed device, implanted in the subcutaneous tissue, with human pancreatic islets housed within its structure. The vascularization is established inside and all around the device to avoid cellular hypoxia. The cover image was prepared by Virginia Facciotto. This is reported by Marco Farina, Andrea Ballerini, Daniel W. Fraga, Eugenia Nicolov, Matthew Hogan, Danilo Demarchi, Francesco Scaglione, Omaima M. Sabek, Philip Horner, Usha Thekkedath, Osama A. Gaber and Alessandro Grattoni, article number 1700169 .