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Recommendations for Comparison of Productivity Between Fed‐Batch and Perfusion Processes
Author(s) -
Bausch Mona,
Schultheiss Christian,
Sieck Jochen B.
Publication year - 2019
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201700721
Subject(s) - productivity , confusion , computer science , biopharmaceutical , process (computing) , upstream (networking) , biochemical engineering , process engineering , microbiology and biotechnology , engineering , biology , economics , telecommunications , psychology , psychoanalysis , macroeconomics , operating system
Due to the growing interest in integrated continuous processing in the biopharmaceutical industry, productivity comparison of batch‐based and continuous processes is considered a challenge. Integrated continuous manufacturing of biopharmaceuticals requires scientists and engineers to collaborate effectively. Differing definitions, for example, of volumetric productivity, may cause confusion in this interdisciplinary field. Therefore, the aim of this communication is to reiterate the standard definitions and their underlying assumptions. Applying them to an exemplary model scenario allows to demonstrate the differences and to develop recommendations for the comparison of productivity of different upstream processes.