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Engineering Mammalian Designer Cells for the Treatment of Metabolic Diseases
Author(s) -
Wang Yidan,
Wang Meiyan,
Dong Kaili,
Ye Haifeng
Publication year - 2018
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201700160
Subject(s) - synthetic biology , metabolic engineering , hyperuricemia , computer science , computational biology , risk analysis (engineering) , neuroscience , biology , bioinformatics , medicine , gene , uric acid , biochemistry
Synthetic biology applies engineering principles to biological systems and has significantly advanced the design of synthetic gene circuits that can reprogram cell activities to perform new functions. The ability to engineer mammalian designer cells with robust therapeutic behaviors has brought new opportunities for treating metabolic diseases. In this review, the authors highlight the most recent advances in the development of synthetic designer cells uploaded with open‐ or closed‐loop gene circuits for the treatment of metabolic disorders including diabetes, hypertension, hyperuricemia, and obesity, and discuss the current technologies and future perspectives in applying these designer cells for clinical applications. In the future, more and more rationally designed cells will be constructed and revolutionized to treat a number of metabolic disorders in an intelligent manner.