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Microbial lipopeptide production and purification bioprocesses, current progress and future challenges
Author(s) -
Coutte François,
Lecouturier Didier,
Dimitrov Krasimir,
Guez JeanSébastien,
Delvigne Frank,
Dhulster Pascal,
Jacques Philippe
Publication year - 2017
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201600566
Subject(s) - quorum sensing , lipopeptide , biochemical engineering , bioreactor , biofilm , bottleneck , amphiphile , chemistry , bacteria , biology , computer science , engineering , organic chemistry , copolymer , genetics , embedded system , polymer
Abstract Lipopeoptides are amphiphilic compounds combining interesting physicochemical properties and biological activities. Due to their high foaming capacity in aerated bioreactor, the development of scalable bioprocesses for their production is a major bottleneck. In addition, the genes involved in the biosynthesis of these lipopeptides are mainly regulated by the quorum sensing, a global regulatory mechanism depending on cell density and known to be activated in biofilms. Several approaches have thus been considered in literature taking into account two criteria, on one side, to favor, control or avoid foam formation and on the other side, to use planktonic or immobilized (biofilm) cells. These different bioprocesses are discussed in the present review along with the purification strategies proposed for extracting and concentrating these biosurfactants.