Premium
Systems biology for understanding and engineering of heterotrophic oleaginous microorganisms
Author(s) -
Park Beom Gi,
Kim Minsuk,
Kim Joonwon,
Yoo Heewang,
Kim ByungGee
Publication year - 2017
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201600104
Subject(s) - metabolic engineering , microorganism , biochemical engineering , systems biology , heterotroph , synthetic biology , biofuel , raw material , biology , production (economics) , microbiology and biotechnology , computational biology , ecology , bacteria , biochemistry , engineering , enzyme , genetics , macroeconomics , economics
Heterotrophic oleaginous microorganisms continue to draw interest as they can accumulate a large amount of lipids which is a promising feedstock for the production of biofuels and oleochemicals. Nutrient limitation, especially nitrogen limitation, is known to effectively trigger the lipid production in these microorganisms. For the aim of developing improved strains, the mechanisms behind the lipid production have been studied for a long time. Nowadays, system‐level understanding of their metabolism and associated metabolic switches is attainable with modern systems biology tools. This work reviews the systems biology studies, based on (i) top‐down, large‐scale ‘omics’ tools, and (ii) bottom‐up, mathematical modeling methods, on the heterotrophic oleaginous microorganisms with an emphasis on further application to metabolic engineering.