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Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals
Author(s) -
Borodina Irina,
Nielsen Jens
Publication year - 2014
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201300445
Subject(s) - yeast , metabolic engineering , saccharomyces cerevisiae , commodity chemicals , microbiology and biotechnology , biochemical engineering , industrial microbiology , nutraceutical , synthetic biology , chemistry , biology , biochemistry , computational biology , enzyme , fermentation , engineering , catalysis
Yeast Saccharomyces cerevisiae is an important industrial host for production of enzymes, pharmaceutical and nutraceutical ingredients and recently also commodity chemicals and biofuels. Here, we review the advances in modeling and synthetic biology tools and how these tools can speed up the development of yeast cell factories. We also present an overview of metabolic engineering strategies for developing yeast strains for production of polymer monomers: lactic, succinic, and cis , cis ‐muconic acids. S. cerevisiae has already firmly established itself as a cell factory in industrial biotechnology and the advances in yeast strain engineering will stimulate development of novel yeast‐based processes for chemicals production.