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Large‐scale production of red blood cells from stem cells: What are the technical challenges ahead?
Author(s) -
Rousseau Guillaume F.,
Giarratana MarieCatherine,
Douay Luc
Publication year - 2014
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201200368
Subject(s) - economic shortage , production (economics) , scale (ratio) , microbiology and biotechnology , biochemical engineering , blood product , risk analysis (engineering) , computer science , business , medicine , intensive care medicine , biology , engineering , surgery , economics , linguistics , philosophy , physics , quantum mechanics , government (linguistics) , macroeconomics
Blood‐transfusion centers regularly face the challenge of donor blood shortages, especially for rare blood groups. The possibility of producing universal red blood cells from stem cells industrially has become a possible alternative since the successful injection of blood generated in vitro into a human being in 2011. Although there remains many biological and regulatory issues concerning the efficacy and safety of this new product, the major challenge today for future clinical applications is switching from the current limited 2‐dimensional production techniques to large‐scale 3‐dimensional bioreactors. In addition to requiring technological breakthroughs, the whole process also has to become at least five‐fold more cost‐efficient to match the current prices of high‐quality blood products. The current review sums up the main biological advances of the past decade, outlines the key biotechnological challenges for the large‐scale cost‐effective production of red blood cells, proposes solutions based on strategies used in the bioindustry and presents the state‐of‐the‐art of large‐scale blood production.