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Electrospun synthetic and natural nanofibers for regenerative medicine and stem cells
Author(s) -
Kai Dan,
Jin Guorui,
Prabhakaran Molamma P.,
Ramakrishna Seeram
Publication year - 2013
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201200249
Subject(s) - nanofiber , electrospinning , regenerative medicine , materials science , nanotechnology , regeneration (biology) , extracellular matrix , tissue engineering , stem cell , polymer , biomedical engineering , microbiology and biotechnology , biology , composite material , engineering
Nanofibers are attractive substrates for tissue regeneration applications because they structurally mimic the native extracellular matrix. Electrospinning has been recognized as one of the most efficient techniques to fabricate polymer nanofibers. Recent research has demonstrated that cellular responses, for example attachment, proliferation and differentiation, can be modulated by tuning nanofiber properties. In combination with other processing techniques, such as particulate leaching or three‐dimensional printing, nanofibrous scaffolds incorporating macroporous networks could be developed to enhance infiltration of cells. Three dimensional nanofiber‐based constructs offer an opportunity to achieve advanced functional tissue regeneration. This review explores the advantageous effects of nanofibers on cell behaviors compared to traditional scaffolds.