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How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?
Author(s) -
Carrondo Manuel J. T.,
Alves Paula M.,
Carinhas Nuno,
Glassey Jarka,
Hesse Friedemann,
Merten OttoWilhelm,
Micheletti Martina,
Noll Thomas,
Oliveira Rui,
Reichl Udo,
Staby Arne,
Teixeira Ana P.,
Weichert Henry,
Mandenius CarlFredrik
Publication year - 2012
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201200226
Subject(s) - industrial production , microbiology and biotechnology , biochemical engineering , relevance (law) , industrial biotechnology , production (economics) , process (computing) , control (management) , computer science , engineering , biology , political science , artificial intelligence , macroeconomics , law , keynesian economics , economics , operating system
This report highlights the potential of measurement, monitoring, modeling and control (M 3 C) methodologies in animal and human cell culture technology. In particular, state‐of‐the‐art of M 3 C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M 3 C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M 3 C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.