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Monitoring and control of microbioreactors: An expert opinion on development needs
Author(s) -
Gernaey Krist V.,
Baganz Frank,
FrancoLara Ezequiel,
Kensy Frank,
Krühne Ulrich,
Luebberstedt Marc,
Marx Uwe,
Palmqvist Eva,
Schmid Andreas,
Schubert Frank,
Mandenius CarlFredrik
Publication year - 2012
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201200157
Subject(s) - bioprocess , expert opinion , control (management) , engineering ethics , microbiology and biotechnology , computer science , risk analysis (engineering) , biochemical engineering , engineering management , engineering , business , biology , medicine , artificial intelligence , chemical engineering , intensive care medicine
This perspective article is based on an expert panel review on microbioreactor applications in biochemical and biomedical engineering that was organized by the M 3 C (measurement, monitoring, modelling and control) Working Group of the European Section of Biochemical Engineering Science (ESBES) in the European Federation of Biotechnology (EFB). The aim of the panel was to provide an updated view on the present status of the subject and to identify critical needs and issues for furthering the successful development of microbioreactor monitoring and control. This will benefit future bioprocess development and in vitro toxicity testing. The article concludes with a set of recommendations for extended use and further development of microbioreactors.