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Microfluidic tools for developmental studies of small model organisms –nematodes, fruit flies, and zebrafish
Author(s) -
Hwang Hyundoo,
Lu Hang
Publication year - 2013
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201200129
Subject(s) - danio , zebrafish , biology , model organism , drosophila melanogaster , microfluidics , computational biology , caenorhabditis elegans , drosophila (subgenus) , microfabrication , drug discovery , nanotechnology , bioinformatics , genetics , gene , medicine , materials science , alternative medicine , pathology , fabrication
Studying the genetics of development with small model organisms such as the zebrafish (Danio Rerio), the fruit fly (Drosophila melanogaster), and the soil‐dwelling nematode (Caenorhabditis elegans), provide unique opportunities for understanding related processes and diseases in humans. These model organisms also have potential for use in drug discovery and toxicity‐screening applications. There have been sweeping developments in microfabrication and microfluidic technologies for manipulating and imaging small objects, including small model organisms, which allow high‐throughput quantitative biological studies. Here, we review recent progress in microfluidic tools able to manipulate small organisms and project future directions and applications of these techniques and technologies.