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Microfabricated particulate drug‐delivery systems
Author(s) -
Pan Jing,
Chan Sui Yung,
Lee Won Gu,
Kang Lifeng
Publication year - 2011
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201100237
Subject(s) - particulates , drug delivery , drug , nanotechnology , chemistry , materials science , medicine , pharmacology , organic chemistry
Micro‐ and nanoparticulate drug‐delivery systems (DDSs) play a significant role in formulation sciences. Most particulate DDSs are scaffold‐free, although some particles are encapsulated inside other biomaterials for controlled release. Despite rapid progress in recent years, challenges still remain in controlling the homogenicity of micro‐/nanoparticles, especially for two crucial factors in particulate DDSs: the size and shape of the particles. Recent approaches make use of microfabrication techniques to generate micro‐/nanoparticles with highly controllable architectures free of scaffolds. This review presents an overview of a burgeoning field of DDSs, which can potentially overcome some drawbacks of conventional techniques for particle fabrication and offer better control of particulate DDSs.