Premium
Miniaturized lensless imaging systems for cell and microorganism visualization in point‐of‐care testing
Author(s) -
Gurkan Umut Atakan,
Moon Sangjun,
Geckil Hikmet,
Xu Feng,
Wang Shuqi,
Lu Tian Jian,
Demirci Utkan
Publication year - 2011
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201000427
Subject(s) - software portability , optofluidics , computer science , point of care testing , emerging technologies , point of care , systems engineering , usability , consumables , visualization , risk analysis (engineering) , nanotechnology , data science , microfluidics , medicine , engineering , human–computer interaction , artificial intelligence , pathology , materials science , business , programming language , marketing
Low‐cost, robust, and user‐friendly diagnostic capabilities at the point‐of‐care (POC) are critical for treating infectious diseases and preventing their spread in developing countries. Recent advances in micro‐ and nanoscale technologies have enabled the merger of optical and fluidic technologies (optofluidics) paving the way for cost‐effective lensless imaging and diagnosis for POC testing in resource‐limited settings. Applications of the emerging lensless imaging technologies include detecting and counting cells of interest, which allows rapid and affordable diagnostic decisions. This review presents the advances in lensless imaging and diagnostic systems, and their potential clinical applications in developing countries. The emerging technologies are reviewed from a POC perspective considering cost effectiveness, portability, sensitivity, throughput and ease of use for resource‐limited settings.