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Deciphering the regulatory codes in bacterial genomes
Author(s) -
Cho ByungKwan,
Palsson Bernhard,
Zengler Karsten
Publication year - 2011
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201000349
Subject(s) - genome , bacterial genome size , operon , computational biology , biology , transcriptome , dna microarray , genetics , prokaryote , regulatory sequence , transcription factor , gene , gene expression , escherichia coli
Interactions between cis ‐regulatory elements and trans ‐acting factors are fundamental for cellular functions such as transcription. With the revolution in microarrays and sequencing technologies, genome‐wide binding locations of trans ‐acting factors are being determined in large numbers. The richness of the genome‐scale information has revealed that the nature of the bacterial transcriptome and regulome are considerably more complex than previously expected. In addition, the emerging view of the bacterial transcriptome is revising the concept of the operon organization of the genome. This review describes current advances in the genome‐scale analysis of the interaction between cis ‐regulatory elements and trans ‐acting factors in microorganisms.