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Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis
Author(s) -
Hyde G. Kevin,
Stewart S. Michael,
Scarel Giovanna,
Parsons Gregory N.,
Shih ChunChe,
Shih ChunMing,
Lin ShingJong,
Su YeaYang,
MonteiroRiviere Nancy A.,
Narayan Roger J.
Publication year - 2011
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201000342
Subject(s) - cellulose , cellulose acetate , wetting , layer (electronics) , scanning electron microscope , contact angle , chemical engineering , materials science , adsorption , atomic layer deposition , titanium dioxide , silicon dioxide , deposition (geology) , titanium , stoichiometry , chemistry , nanotechnology , inorganic chemistry , organic chemistry , composite material , metallurgy , paleontology , sediment , engineering , biology
TiO 2 films may be used to alter the wettability and hemocompatibility of cellulose materials. In this study, pure and stoichiometric TiO 2 films were grown using atomic layer deposition on both silicon and cellulose substrates. The films were grown with uniform thicknesses and with a growth rate in agreement with literature results. The TiO 2 films were shown to profoundly alter the water contact angle values of cellulose in a manner dependent upon processing characteristics. Higher amounts of protein adsorption indicated by blurry areas on images generated by scanning electron microscopy were noted on TiO 2 ‐coated cellulose acetate than on uncoated cellulose acetate. These results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood‐contacting biomaterials.