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Viral transformation for production of personalized type I interferons
Author(s) -
Xu Dongsheng,
Zhang Luwen
Publication year - 2010
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.201000038
Subject(s) - virology , interferon , transformation (genetics) , personalized medicine , virus , priming (agriculture) , hepatitis c virus , immunology , biology , medicine , computational biology , bioinformatics , genetics , gene , germination , botany
Type I interferons (IFN) are cytokines with many functions and have been widely used to treat many human diseases such as hepatitis C virus infection. Using the viral transformation and priming properties of Epstein‐Barr virus, we have developed a system that can produce high levels of “personalized” IFNs, which are produced from the cells of the patient to whom the IFNs are to be administrated. We demonstrate the feasibility of the system. This seems to be the first report for the establishment of a personalized IFN‐production system. The personalized IFNs could have a longer circulation time, fewer side effects but higher efficacy. We anticipate that the system can provide an improved form of IFN for medical uses.