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O ‐acetylated sialic acids: Multifaceted role in childhood acute lymphoblastic leukaemia
Author(s) -
Chowdhury Suchandra,
Mandal Chitra
Publication year - 2009
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200800253
Subject(s) - lymphoblast , minimal residual disease , sialic acid , immunology , disease , malignancy , population , malignant transformation , medicine , acute lymphocytic leukemia , glycoprotein , cancer research , biology , leukemia , lymphoblastic leukemia , biochemistry , genetics , cell culture , environmental health
Childhood acute lymphoblastic leukaemia (ALL), a malignant transformation of the lymphoblasts, is highly responsive to chemotherapy. However, due to certain inadequacy in detection of minimal residual disease (MRD), relapse is a common phenomenon. To address this question, the present review deals with the induction of an unique O ‐acetyl derivative of sialic acid on a few disease‐associated glycoproteins and glycolipids at the onset of childhood ALL, a finding of our group in the last decade. This information has been successfully utilized for diagnosis and prognosis of the disease. Existing literature is included for comparison. Additionally, cell surface overexpression of 9‐ O ‐acetylated sialoglycoproteins and antibodies against them present in patients' sera aid the survival of the malignant lymphoblasts and suggest a multifaceted role played by these molecules. Taken together, monitoring these molecules helps not only in unravelling the biology of this paediatric malignancy but also in personalizing the treatment strategies for the betterment of the patient population.