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The presence of rRNA sequences in polyadenylated RNA and its potential functions
Author(s) -
Kong Qiongman,
Stockinger Michael P.,
Chang Yueming,
Tashiro Hirofumi,
Lin Chienliang Glenn
Publication year - 2008
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200800122
Subject(s) - polyadenylation , ribosomal rna , rna , biology , 23s ribosomal rna , 5.8s ribosomal rna , nucleotide , directionality , genetics , computational biology , gene , non coding rna , ribosome
Accumulating evidence has shown that various lengths of ribosomal RNA (rRNA) sequences are widely present in polyadenylated RNA. This review article will discuss these polyadenylated rRNAcontaining transcripts (PART). PART are highly abundant and widely expressed in various tissues. It appears that there may be two types of PART. One type, type I, contains the rRNA segments (from ∼10 nucleotides up to several hundred nucleotides) located within the transcripts. It has been demonstrated that short rRNA sequences within type I PART may function as cis‐regulatory elements that regulate translational efficiency. The other type, type II, contains large portions or almost entire sequences of rRNA with a cap at the 5' end and poly(A) at 3' end. Recent work has shown that some type II PART have functional significance for some neurodegenerative disease processes and may play an important role in the pathogenesis of diseases. Further investigation in this area is critical to understanding the basic biology of PART and the potential role of PART in diseases.