Role of Kinases in Neuronal Function

Cover illustration: Role of Cdk5 in neuronal function. Crystal structure of indirubin‐38‐monoxime in complex with Cdk5/p25 [1]. The inhibitor binds in the ATP‐binding pocket of the catalytic subunit, mainly through hydrophobic interaction and two hydrogen bonds with Leu83. Indirubin‐38‐monoxime is shown as a ball‐and‐stick model, and the molecular surface of Cdk5/p25 is coloured according to electrostatic potential, with blue and red representing positive and negative potential, respectively. The figure was created with the program GRASP [2]. Courtesy of Claudia Crovace, Aldo Tarricone and Andrea Musacchio.