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Role of Kinases in Neuronal Function
Publication year - 2007
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200790084
Subject(s) - kinase , function (biology) , chemistry , computational biology , biochemistry , biology , microbiology and biotechnology
Cover illustration: Role of Cdk5 in neuronal function. Crystal structure of indirubin‐38‐monoxime in complex with Cdk5/p25 [1]. The inhibitor binds in the ATP‐binding pocket of the catalytic subunit, mainly through hydrophobic interaction and two hydrogen bonds with Leu83. Indirubin‐38‐monoxime is shown as a ball‐and‐stick model, and the molecular surface of Cdk5/p25 is coloured according to electrostatic potential, with blue and red representing positive and negative potential, respectively. The figure was created with the program GRASP [2]. Courtesy of Claudia Crovace, Aldo Tarricone and Andrea Musacchio.