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Technical aspects of biocatalysis in non‐CO 2 ‐based supercritical fluids
Author(s) -
Karmee Sanjib Kumar,
Casiraghi Laura,
Greiner Lasse
Publication year - 2008
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200700199
Subject(s) - biocatalysis , supercritical fluid , supercritical carbon dioxide , biotransformation , catalysis , chemistry , solvent , organic chemistry , biochemical engineering , enantioselective synthesis , reaction mechanism , enzyme , engineering
The number of biotransformation processes is increasing rapidly. Part of this success is based on the inherent properties of enzymes as chemo‐, regio‐, and enantioselective catalysts. Supercritical fluids (scF) are superior solvents inheriting adjustable and partly unique physical properties. These can be advantageously combined with biotransformations, as solvent power responds to pressure and temperature changes according to the reaction requirements. Among the scF, supercritical carbon dioxide has undoubtedly gained the highest attention. However, other scF are also recognized to enlarge the possibilities. Among these CH 4 , C 2 H 6 , C 2 H 4 , C 3 H 8 , CHF 3 , and SF 6 are used as scF for biocatalysis. This review focuses on the use of non‐CO 2 based scF for biotransformations. Wherever possible, special emphasis is given on the industrial viability of different biocatalytic processes.