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Biotechnology of flavonoids and other phenylpropanoid‐derived natural products. Part II: Reconstruction of multienzyme pathways in plants and microbes
Author(s) -
Ververidis Filippos,
Trantas Emmanouil,
Douglas Carl,
Vollmer Guenter,
Kretzschmar Georg,
Panopoulos Nickolas
Publication year - 2007
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200700184
Subject(s) - phenylpropanoid , biology , human health , microbiology and biotechnology , chemistry , biochemistry , biosynthesis , enzyme , medicine , environmental health
Plant natural products derived from phenylalanine and the phenylpropanoid pathways are impressive in their chemical diversity and are the result of plant evolution, which has selected for the acquisition of large repertoires of pigments, structural and defensive compounds, all derived from a phenylpropanoid backbone via the plant‐specific phenylpropanoid pathway. These compounds are important in plant growth, development and responses to environmental stresses and thus can have large impacts on agricultural productivity. While plant‐based medicines containing phenylpropanoid‐derived active components have long been used by humans, the benefits of specific flavonoids and other phenylpropanoid‐derived compounds to human health and their potential for long‐term health benefits have only been recognized more recently. In this part of the review, we discuss in detail the recent strategies and achievements used in the reconstruction of multienzyme pathways in plants and microbes in an effort to be able to attain higher amounts of the desired flavonoids and stilbenoids exploiting their beneficial properties as analyzed extensively in Part I of this review.