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Macroporous gel particles as robust macroporous matrices for cell immobilization
Author(s) -
Plieva Fatima M.,
Oknianska Alina,
Degerman Eva,
Mattiasson Bo
Publication year - 2008
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200700134
Subject(s) - chemistry , chromatography , chemical engineering , materials science , engineering
A new design of robust matrices for cell immobilization is described. Macroporous gels (MGs) with immobilized microbial cells were prepared at subzero temperatures and were formed inside a plastic core (so‐called, protective housing). Due to the protective housing the macroporous gel particles with immobilized cells can be used in well‐stirred bioreactors. High retained activity of yeast (77–92%) and Escherichia coli (50–91%) cells immobilized in MGs after drying and storage in the dried state was due to the high structural stability and heterogeneous porous structure of the MGs.