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Cerebral ischemia, cell cycle elements and Cdk5
Author(s) -
Timsit Serge,
Menn Bénédicte
Publication year - 2007
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200700072
Subject(s) - neuroprotection , cyclin dependent kinase , cyclin dependent kinase 5 , programmed cell death , cell cycle , mitosis , neuroscience , kinase , microbiology and biotechnology , ischemia , biology , stroke (engine) , cyclin , apoptosis , medicine , protein kinase a , cyclin dependent kinase 2 , biochemistry , mechanical engineering , engineering
Stroke is a devastating disorder that significantly contributes to death, disability, and healthcare costs. New therapeutic strategies have been recently focusing on the development of neuroprotective agents that could halt the underlying mechanisms of neuronal death leading to brain damage. Accumulating evidence implicates proteins that are normally involved in the regulation of the cell cycle to neuronal death following ischemic insult, suggesting that these proteins could be suitable targets for stroke therapy. In this brief review, we present in vitro and in vivo arguments linking cell cycle molecules, i.e. , cyclins, mitotic cyclin‐dependent kinases (Cdks), as well as non‐mitotic Cdk5, to ischemic neuronal death. We also report the evaluation of the potential of Cdk inhibitors as neuroprotective strategy for ischemic injury.