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Dielectrophoresis based‐cell patterning for tissue engineering
Author(s) -
Lin RueiZeng,
Ho ChenTa,
Liu ChengHsien,
Chang HwanYou
Publication year - 2006
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200600112
Subject(s) - dielectrophoresis , regenerative medicine , tissue engineering , nanotechnology , computer science , cell , materials science , biomedical engineering , stem cell , microbiology and biotechnology , biology , engineering , microfluidics , genetics
Engineering functional tissues and organs in vitro is considered integral to regenerative medicine. Many recent cell patterning technique developments position cells at a pre‐designated pattern to improve tissue engineering efficiency and quality and to facilitate 3‐D cell‐cell interaction exploration. Among these techniques, dielectrophoresis (DEP)‐based cell patterning advantageously offers speed, ease of operation, low degree of cell damage, and precision. This article reviews recent advances in DEP‐based patterning techniques, including electrode design, suitable buffer and hydrogel, effects of the electric current to cells, combination potential with other techniques, as well as efforts to generate 3‐D tissues.