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Prospective use of electrospun ultra‐fine silicate fibers for bone tissue engineering
Author(s) -
Sakai Shinji,
Yamada Yusuke,
Yamaguchi Tetsu,
Kawakami Koei
Publication year - 2006
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200600054
Subject(s) - electrospinning , silicate , materials science , apatite , chemical engineering , tissue engineering , simulated body fluid , bone tissue , composite material , biomedical engineering , polymer , medicine , engineering
Electrospinning involves the generation of a jet of viscous solution, and results in the formation of ultra‐fine fibers. Silicate fibers prepared using this technology and via the sol‐gel process were evaluated as scaffolds for bone tissue engineering. We found that human osteoblastic MG63 cells successfully adhered on individual silicate fibers, and proliferated on them. In an apatite‐formation ability study, spherical particles covered the fibers after soaking in simulated body fluid for 7 days. Energy dispersive X‐ray analysis revealed that Ca/P atomic ratio of the particles was similar to that of human bone. In addition, X‐ray diffraction analysis revealed that crystalline structure of the particles agreed with that of apatite. These results suggest that electrospun silicate fibers are a potential candidate for scaffolding material in bone tissue engineering.