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Human and bovine lactoferrins in the milk of recombinant human lactoferrin‐transgenic dairy cows during lactation
Author(s) -
Hyvönen Paula,
Suojala Leena,
Haaranen Johanna,
von Wright Atte,
Pyörälä Satu
Publication year - 2006
Publication title -
biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.144
H-Index - 84
eISSN - 1860-7314
pISSN - 1860-6768
DOI - 10.1002/biot.200600016
Subject(s) - lactoferrin , lactation , colostrum , ice calving , recombinant dna , zoology , mammary gland , biology , somatic cell count , transgene , dairy cattle , andrology , chemistry , immunology , pregnancy , biochemistry , medicine , antibody , gene , genetics , cancer , breast cancer
Seven Friesian human lactoferrin (hLf)‐transgenic primiparous dairy cows expressing recombinant hLf (rhLf) in their milk were included in the study. After calving, concentrations of rhLf and bovine LF (bLf) in the milk, somatic cell count and milk yield were determined. The concentration of rhLf was found to be constant, about 2.9 mg/mL, throughout the early lactation period of 3 months. The concentration of bLf in colostrum was higher after calving, but decreased rapidly during the first days of lactation. The mean concentration of bLf was 0.15 mg/mL, but concentrations varied between cows from 0.07 mg/mL to 0.26 mg/mL. Based on that, it may be possible to improve the non‐specific host defence mechanism in the mammary gland of dairy cows by enhancing the content of rhLf in the milk.