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CD40/CD40L signaling and its implication in health and disease
Author(s) -
Chatzigeorgiou Antonios,
Lyberi Maria,
Chatzilymperis Gregorios,
Nezos Adrianos,
Kamper Elli
Publication year - 2009
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.62
Subject(s) - cd40 , disease , business , medicine , biology , genetics , cytotoxic t cell , in vitro
CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B‐cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate and finally their implication in the pathophysiology of inflammatory and autoimmune diseases. © 2009 International Union of Biochemistry and Molecular Biology, Inc.