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Antioxidative activity of sulfur‐containing compounds in Allium species for human LDL oxidation in vitro
Author(s) -
Nishimura Hiroyuki,
Higuchi Ohki,
Tateshita Koutaro
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.552210154
Subject(s) - organosulfur compounds , chemistry , sulfur , allium , antioxidant , in vitro , low density lipoprotein , organic chemistry , biochemistry , medicinal chemistry , botany , cholesterol , biology
Sulfur‐containing compounds contributing to health promotion in Allium species are produced via enzymic and thermochemical reactions. Sulfur‐containing amino acids and volatile organosulfur compounds were prepared for an antioxidative assay. The inhibitory activity of S‐alk(en)yl‐L‐cysteines and their sulfoxides, volatile alk(en)yl disulfides and trisulfides, and vinyldithiins in Allium species against lipid hydroperoxide (LOOH) formation in human low‐density lipoprotein (LDL) was examined. It was elucidated that the alk(en)yl substituents (methyl, propyl, and allyl) and the number of sulfur atoms in the compounds were important for the antioxidative activity. 3,4‐Dihydro‐3‐vinyl‐1,2‐dithiin, which is produced by a thermochemical reaction of allyl 2‐propenethiosulfinate, exhibited the highest antioxidative activity of human LDL among sulfur‐containing compounds.