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Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice
Author(s) -
Fukuda Toshiyuki,
Ito Hideyuki,
Yoshida Takashi
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.552210148
Subject(s) - oxidative stress , polyphenol , in vivo , antioxidant , chemistry , type 2 diabetes , diabetes mellitus , oxidative phosphorylation , pharmacology , biochemistry , food science , endocrinology , biology , microbiology and biotechnology
We examined the in vivo antioxidative effect of a polyphenol‐rich walnut extract on oxidative stress in mice with type 2 diabetes. C57BL/KsJ‐db/db mice were used as an accelerated oxidative animal model. The oral administration of the walnut polyphenol fraction at 200∼mg/kg body weight for 4 weeks caused a significant decrease in the level of urinary 8‐hydroxy‐2'‐deoxyguanosin, which is an in vivo marker of oxidative stress. These results imply that walnut polyphenols have both in vitro and in vivo antioxidant effects.