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Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata , and ampelopsin
Author(s) -
Murakami Toshiyuki,
Miyakoshi Masazumi,
Araho Daisuke,
Mizutani Kenji,
Kambara Toshimitsu,
Ikeda Takao,
Chou WenHua,
Inukai Mihoko,
Takenaka Asako,
Igarashi Kiharu
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.552210136
Subject(s) - chemistry , oxidative stress , in vivo , pharmacology , traditional medicine , biochemistry , biology , medicine , microbiology and biotechnology
Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D‐galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, α‐tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.