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Liquid chromatography‐mass spectrometry in metabolite profiling
Author(s) -
Juo ChiunGung,
Chiu Daniel TsunYee,
Shiao MingShi
Publication year - 2008
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520340207
Subject(s) - metabolomics , chromatography , mass spectrometry , chemistry , metabolite , metabolite profiling , ion mobility spectrometry , liquid chromatography–mass spectrometry , profiling (computer programming) , computer science , biochemistry , operating system
Recent advances in the use of liquid chromatography‐mass spectrometry for the study of metabolomics are reviewed. Sample preparations of biofluids and practical aspects of ultra‐high pressure liquid chromatography are discussed. Applicability of different kinds of mass spectrometers for metabolite profiling is described. New tools‐ion mobility spectroscopy and automated chip‐based nanoelectrospray system with potentials to be applied in the metabolomics analysis are described.