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Oxidative damage markers and antioxidants in patients with acute myocardial infarction and their clinical significance
Author(s) -
Gu PoWen,
Wang YiLi,
Li JuiMing,
Chiu Daniel TsunYee,
Cheng MeiLing,
Chen ChinMing
Publication year - 2008
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520340205
Subject(s) - oxidative stress , myeloperoxidase , medicine , myocardial infarction , antioxidant , risk factor , cardiology , glutathione peroxidase , vitamin e , inflammation , biochemistry , superoxide dismutase , biology
Oxidative stress has been associated with degenerative diseases such as cardiovascular and neurodegenerative diseases. Acute myocardial infarction (AMI) is the major cause of death among cardiovascular diseases. Inflammation, major risk factor of AMI, is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and subsequent oxidant generation. It has been hypothesized that oxidative stress is a risk factor for AMI. To test this hypothesis, we studied profiles of oxidative damage and antioxidants in patients with AMI. The levels of MPO, 8‐OHdG, and 3‐Cl‐Tyr were higher in blood specimens from AMI patients than in those of controls. Antioxidant levels, such as vitamin E and glutathione peroxidase, were significantly lower in these patients. The GSH/GSSG ratio, indicative of redox status, was also lower in AMI patients. Such findings suggest that these AMI patients experience increased oxidative stress. Moreover, markers in combination are better for evaluating antioxidant status and monitoring cardiac events than the same markers used separately.