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Bilberry inhibits angiogenesis in chick chorioallontoic membrane
Author(s) -
Ozgurtas Taner,
Aydin Ibrahim,
Tapan Serkan,
Avci Ozgur,
Erbil M. Kemal
Publication year - 2008
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520330301
Subject(s) - angiogenesis , bilberry , neovascularization , in vivo , chorioallantoic membrane , microbiology and biotechnology , chemistry , biology , cancer research , food science
Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. Bilberry has been traditionally used as a folk medicine for some countries. The purpose of the present study was to evaluate the effect of bilberry in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, bilberry inhibited angiogenesis in a concentration‐dependent manner. Compared with the normal group, bilberry group has significant decreased vessels proliferation. These results provide evidence that bilberry inhibits angiogenesis and may be useful for treating angiogenesis‐dependent human diseases.