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Aging skin is functionally anaerobic: Importance of coenzyme Q 10 for anti aging skin care
Author(s) -
Prahl S.,
Kueper T.,
Biernoth T.,
Wöhrmann Y.,
Münster A.,
Fürstenau M.,
Schmidt M.,
Schulze C.,
Wittern K.P.,
Wenck H.,
Muhr G.M.,
Blatt T.
Publication year - 2008
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520320129
Subject(s) - mitochondrion , anaerobic exercise , function (biology) , energy metabolism , human skin , metabolism , in vivo , cofactor , biology , cellular metabolism , microbiology and biotechnology , physiology , gerontology , biochemistry , medicine , genetics , endocrinology , enzyme
The functional loss of mitochondria represents an inherent part in modern theories trying to explain the cutaneous aging process. The present study shows significant age‐dependent differences in mitochondrial function of keratinocytes isolated from skin biopsies of young and old donors. Our data let us postulate that energy metabolism shifts to a predominantly nonmitochondrial pathway and is therefore functionally anaerobic with advancing age. CoQ 10 positively influences the age‐affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ 10 is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo .