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Oxidative stress, endothelial function and coenzyme Q 10
Author(s) -
Belardinelli Romualdo,
Tiano Luca,
Littarru Gian Paolo
Publication year - 2008
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520320115
Subject(s) - peroxynitrite , oxidative stress , nitric oxide , superoxide dismutase , reactive oxygen species , antioxidant , superoxide , chemistry , oxidative phosphorylation , pharmacology , biochemistry , endothelium , homeostasis , peroxynitrous acid , oxygen , biophysics , medicine , biology , enzyme , organic chemistry
Reactive oxygen species seem to play an important role in vascular homeostasis. In conditions of high oxidative stress, such as chronic heart failure and multiple coronary risk factors, the rate of inactivation of nitric oxide to peroxynitrite by superoxide anions may be reduced by CoQ 10 , which can also protect against nitrosative damage. CoQ 10 may also influence vascular function indirectly via inhibition of oxidative damage to LDL. Patients with lower levels of extracellular superoxide dismutase (ecSOD) demonstrate greater improvements than patients with normal ec‐SOD levels, suggesting that the higher the oxidative stress the greater the improvement in the endothelium‐dependent relaxation after the administration of a compound with antioxidant properties like CoQ 10 . Future studies are needed to inquire whether these effects may translate into benefits in clinical practice.