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BTB/POZ domain of speckle‐type POZ protein (SPOP) confers proapoptotic function in HeLa cells
Author(s) -
Byun Boohyeong,
Tak Heejae,
Joe Cheol O.
Publication year - 2007
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520310303
Subject(s) - hela , chemistry , microbiology and biotechnology , domain (mathematical analysis) , function (biology) , cancer research , biology , biochemistry , cell , mathematical analysis , mathematics
The proapoptotic function of SPOP protein was investigated in HeLa cells. HeLa cells underwent apoptosis by the overexpression of SPOP. Studies using SPOP deletion mutants suggest that BTB/POZ domain of SPOP protein is important for the induction of apoptosis in transfected cells. This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C‐terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis.