BTB/POZ domain of speckle‐type POZ protein (SPOP) confers proapoptotic function in HeLa cells | Zendy

Byun Boohyeong | Zendy; Tak Heejae | Zendy; Joe Cheol O. | Zendy

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BTB/POZ domain of speckle‐type POZ protein (SPOP) confers proapoptotic function in HeLa cells

Author(s) -

Byun Boohyeong,

Tak Heejae,

Joe Cheol O.

Publication year - 2007

Publication title -

biofactors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.204

H-Index - 94

eISSN - 1872-8081

pISSN - 0951-6433

DOI - 10.1002/biof.5520310303

Subject(s) - hela , chemistry , microbiology and biotechnology , domain (mathematical analysis) , function (biology) , cancer research , biology , biochemistry , cell , mathematical analysis , mathematics

The proapoptotic function of SPOP protein was investigated in HeLa cells. HeLa cells underwent apoptosis by the overexpression of SPOP. Studies using SPOP deletion mutants suggest that BTB/POZ domain of SPOP protein is important for the induction of apoptosis in transfected cells. This study first proposes the proapoptotic aspect of the BTB/POZ domain of SPOP protein based on the finding that cells expressing the C‐terminal fragment of SPOP containing the BTB/POZ domain underwent apoptosis.

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