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Immobilization of derivatized dextran nanoparticles on konjac glucomannan/chitosan film as a novel wound dressing
Author(s) -
Zhang Hui,
Gu ChunHu,
Wu Hong,
Fan Li,
Li Fei,
Yang Fan,
Yang Qian
Publication year - 2007
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520300404
Subject(s) - chitosan , dextran , glucomannan , wound dressing , chemistry , nanoparticle , nanotechnology , chemical engineering , materials science , chromatography , food science , organic chemistry , composite material , engineering
The aim of this study was to prepare konjac glucomannan (KGM)/chitosan (CS) film containing glycidyl methacrylate derivatized dextran (dex‐GMA)/acrylic acid(AAc) nanoparticles loaded with antibacterial agent. In this study, An optimized procedure chosen from three methods was used to prepare Erythromycin (EM)‐loaded poly(dex‐GMA/AAc) nanoparticles and obtained nanoparticles ranged from 50–200 nm. Film was found to have equilibrium water content (EWC) 99.3% which could prevent exudates on wound bed from accumulating and also have excellent water adsorption 2362.3 ± 55.2%; the water vapor transmission rate (WVTR) was 2335 ± 36 gm −2 day −1 and evaporative water loss from the film (EWL) was approximately 10% after 1 h and within 6 h it increased to 90%. Drug release of film containing nanoparticles or absent was determined, within 22 h accumulative release was 40.3%, 72.5% respectively. In conclusion, KGM/CS film containing nanoparticles could not only maintain a moist environment over wound bed in moderate to heavily exuding wound but also provide a continuous and sustained release of the antibacterial agent on the wound surface, which could be potential wound dressing.