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Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP
Author(s) -
Murad Leonardo Borges,
Guimarães Marcela Rodrigues Moreira,
Vianna Ucia Marques
Publication year - 2007
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520300102
Subject(s) - coenzyme q10 , chemistry , medicine , biochemistry
Abstract Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the effect in vivo has not been demonstrated yet. Thus, rats SHRSP male were divided in two groups: treated and controls ( n = 6, each). The treated group received 10 mg/Kg − /body weight of decylubiquinone diluted in coconut oil by oral gavage during four weeks. Control rats just received the vehicle. Body weight, diuresis, food and water intake, systolic blood pressure, total cholesterol, LDL‐cholesterol, HDL‐cholesterol, triglycerides, blood glucose levels and malondialdehyde were determined. There were a significant ( p < 0.05) reduction on systolic blood pressure, plasma malondialdehyde, total cholesterol and LDL‐cholesterol in the treated group. Additionally, HDL‐cholesterol also increased significantly. However, body weight, diuresis, food and water intake, blood glucose levels and triglycerides did not alter after treatment. Thus, decylubiquinone can be a new antihypertensive, hypolipidemic and antioxidant agent on the prevention and treatment of diseases linked to oxidative stress.