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Enhanced cardiovascular function and energy level by a novel chromium (III)‐supplement
Author(s) -
Thirunavukkarasu Mahesh,
Penumathsa Sureshvarma,
Juhasz Bela,
Zhan Lijun,
Bagchi Manashi,
Yasmin Taharat,
Shara Michael A.,
Thatte Hemant S.,
Maulik Nilanjana
Publication year - 2006
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520270106
Subject(s) - withania somnifera , taurine , medicine , endocrinology , aspartate transaminase , caffeine , adenosine monophosphate , creatine , chemistry , adenosine diphosphate , alanine transaminase , creatine kinase , glutamine , amino acid , adenosine , biochemistry , alkaline phosphatase , enzyme , platelet , alternative medicine , platelet aggregation , pathology
The impetus for the novel Energy Formula (EF) which combines the niacin‐bound chromium (III) (0.45%) (NBC), standardized extract of Withania somnifera extracts (10.71%), caffeine (22.76%), D‐ribose (10.71%) and selected amino acids such as phenylalanine, taurine and glutamine (55.37%) was based on the knowledge of the cardioprotective potentials of the Withania somnifera extract, caffeine and D‐ribose as well as their abilities to increase energy levels and the abilities of amino acids to increase the muscle mass and energy levels. The effect of oral supplementation of EF on the safety, myocardial energy levels and cardioprotective ability were investigated in an ischemic‐reperfused myocardium model in both male and female Sprague‐Dawley rats over 90 days trial period. At the completion of 90 days, the EF‐treated male and female rats gained 9.4% and 3.1% less body weights, respectively, as compared to their corresponding control groups. No significant difference was found in the levels of lipid peroxidation and activities of hepatic Aspartate transaminase, Alanine transaminase and Alkaline phosphatase in EF treatment when compared with control animals. The male and female rat hearts were subjected to 30 min of global ischemia followed by 2 h of reperfusion at 30 and 90 days of EF treatment. Cardiovascular functions including heart rate, coronary flow, aortic flow, dp/dt max , left ventricular developed pressure (LVDP) and infarct size were monitored. The levels of myocardial adenosine triphosphate (ATP), creatine phosphate (CP), phospho‐adenosine monophosphate kinase (p‐AMPK) levels, were analyzed at the end of 30 and 90 days of treatment. Significant improvement was observed in all parameters in the EF treatment groups as compared to their corresponding controls. Thus the niacin‐bound chromium (III) based energy formula is safe and effective supplement to boost energy levels and cardioprotection.