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Thioredoxin‐binding protein‐2 (TBP‐2): Its potential roles in the aging process
Author(s) -
Yoshida Toru,
Kondo Norihiko,
Oka ShinIchi,
Ahsan Md Kaimul,
Hara Tomijiro,
Masutani Hiroshi,
Nakamura Hajime,
Ab Junji Yodoi
Publication year - 2006
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520270105
Subject(s) - thioredoxin , microbiology and biotechnology , ap 1 transcription factor , cell growth , ectopic expression , intracellular , cell cycle , senescence , lipid metabolism , chemistry , metabolism , biology , biochemistry , cell , gene expression , gene
Thioredoxin (TRX) binding protein‐2 (TBP‐2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP‐2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP‐2 suppresses cellular proliferation along with cell cycle arrest at the G1 phase. TBP‐2 was also reported to be a cellular senescence‐associated gene. Besides the retardation of cellular growth, the reduction of white adipose, and alteration of the energy pathway are involved in several features of the aging process. We have generated TBP‐2 genetically modified mice and found that TBP‐2 is closely linked to lipid metabolism. Indeed, TBP‐2 has been suggesting to be related to familial combined hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP‐2 in the regulation of energy utilization connected to the aging process.