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Evaluation of chemopreventive action of Ginsenoside Rp1
Author(s) -
Kumar Ashok,
Kumar Madhu,
Panwar Meenakshi,
Samarth Ravindra M.,
Park Tae Yoon,
Park Myung Hwan,
Kimura Hiroshi
Publication year - 2006
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520260104
Subject(s) - glutathione , glutathione reductase , glutathione peroxidase , chemistry , superoxide dismutase , lipid peroxidation , dmba , catalase , pharmacology , antioxidant , biochemistry , enzyme , biology , carcinogenesis , gene
We evaluated the chemopreventive properties of Ginsenoside Rp1 on 7,12‐Dimethyl benz (a) anthracene (DMBA) skin papillomagenesis in Swiss albino mice. A significant reduction in values of tumor incidence, tumor burden, and cumulative number of papilloma was observed in mice treated orally with Ginsenoside Rp1 continuously at pre‐, peri‐ and post‐initiational stages of papillomagenesis as compared to the control group. Chemopreventive potential of Ginsenoside Rp1 was also observed on the skin metabolizing enzymes in Swiss albino mice. Ginsenoside Rp1 produced a significant elevation in the skin microsomal cytochrome p‐450 and cytochrome b5, glutathione S‐transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPX), glutathione reductase (GR), DT‐diaphorase, superoxide dismutase (SOD) and catalase levels in the group of mice treated with Ginsenoside Rp1 for seven consecutive days. However, there was significant decrease in lipid peroxidation (LPO) level in Ginsenoside Rp1 treated group.