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Effects of vitamin C and aspirin in ischemic stroke‐related lipid peroxidation: Results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study
Author(s) -
Polidori M. Cristina,
Praticó Domenico,
Ingegni Tiziana,
Mariani Elena,
Spazzafumo Liana,
Sindaco Paola Del,
Cecchetti Roberta,
Yao Yuemang,
Ricci Stefano,
Cherubini Antonio,
Stahl Wilhelm,
Sies Helmut,
Senin Umberto,
Mecocci Patrizia,
Group Avasas Study
Publication year - 2005
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520240131
Subject(s) - aspirin , ascorbic acid , medicine , vitamin c , lipid peroxidation , stroke (engine) , antioxidant , vitamin e , vitamin , gastroenterology , oxidative stress , pharmacology , biochemistry , chemistry , food science , mechanical engineering , engineering
A condition of oxidative stress is known to occur in ischemic stroke, the current therapeutic intervention of which is largely limited to thrombolysis. To assess the effect of vitamin C ‐ in conjunction to aspirin ‐ in ischemic stroke‐related lipid peroxidation, we measured plasma levels of ascorbate, of 8,12‐isoprostanes F 2α ‐VI (8,12‐iPF 2α ‐VI) and activities and levels of a broad spectrum of antioxidant enzymes and micronutrients in stroke patients randomized to receive, from stroke onset and up to three months, either vitamin C (200 mg/day) plus aspirin (300 mg/day) or only aspirin (300 mg/day). By the end of the first week, patients treated with vitamin C plus aspirin had higher vitamin C levels ( p = 0.02) and lower 8,12‐iPF 2α ‐VI levels ( p = 0.01) than patients treated with aspirin alone. The significance was maintained for the increase of vitamin C after three months of therapy ( p < 0.01). The clinical functional outcome for both groups of patients similarly ameliorated after three months of treatment. We conclude that vitamin C, at the dose of 200∼mg/day and in conjunction with aspirin, significantly decreases ischemic stroke‐related lipid peroxidation in humans. Further studies are warranted to clarify whether the use of vitamin C may add clinical long‐term beneficial effects in patients with stroke.