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Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one‐week intake of broccoli sprouts
Author(s) -
Murashima Megumi,
Watanabe Shaw,
Zhuo XingGang,
Uehara Mariko,
Kurashige Atsushi
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520220154
Subject(s) - oxidative stress , chemistry , metabolism , cholesterol , urine , medicine , endocrinology , food science , biochemistry , biology
Little is known about the direct effect of broccoli sprouts on human health. So we investigated the effect of broccoli sprouts on the induction of various biochemical oxidative stress markers. Twelve healthy subjects (6 males and 6 females) consumed fresh broccoli sprouts (100 g/day) for 1 week for a phase 1 study. Before and after the treatment, biochemical examination was conducted and natural killer cell activity, plasma amino acids, plasma PCOOH (phosphatidylcholine hydroperoxide), the serum coenzyme Q 10 , urinary 8‐isoprostane, and urinary 8‐OHdG (8‐hydroxydeoxyguanosine) were measured. With treatment, total cholesterol and LDL cholesterol decreased, and HDL cholesterol increased significantly. Plasma cystine decreased significantly. All subjects showed reduced PCOOH, 8‐isoprostane and 8‐OHdG, and increased CoQ 10 H 2 /CoQ 10 ratio. Only one week intake of broccoli sprouts improved cholesterol metabolism and decreased oxidative stress markers.