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Anti‐adipogenic effects of Garcinia extract on the lipid droplet accumulation and the expression of transcription factor
Author(s) -
Kim MyungSunny,
Kim JinKyung,
Kwon DaeYoung,
Park Raekil
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520220140
Subject(s) - adipogenesis , garcinia , transcription factor , chemistry , lipid droplet , microbiology and biotechnology , cytoplasm , 3t3 l1 , biochemistry , biology , in vitro , gene , botany
Garcinia extract was used as a potential anti‐obesity agent. In this study, we found that Garcinia extract inhibits the cytoplasmic lipid accumulation as well as adipogenic differentiation of preadipocytes. The mechanisms that regulate the inhibition of insulin‐induced differentiation by Garcinia extracts include the inhibition of expression of the early adipogenic transcription factor, CCAAT element binding protein (C/EBP)α that regulate adipogenesis. These results suggest that the specific targets of Garcinia extract on differentiation process of 3T3‐L1 cells could be, at least, early adipogenic differentiation factor.