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Enhancement of insulin sensitivity in adipocytes by ginger
Author(s) -
Sekiya Keizo,
Ohtani Atsuko,
Kusano Shuichi
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520220130
Subject(s) - insulin sensitivity , sensitivity (control systems) , insulin resistance , insulin , chemistry , medicine , endocrinology , engineering , electronic engineering
Antidiabetic and hypoglycemic drugs have been reported to enhance adipocyte differentiation of 3T3‐L1 preadipocytes. We previously reported that ginseng (active constituents: ginsenosides) enhanced the differentiation [1]. In this experiment, effect of some ginger group food extracts on the adipocyte differentiation was investigated using cultured mouse 3T3‐L1 preadipocytes. 3T3‐L1 cells were grown as monolayer cultures at 37°C in DMEM supplemented by 10% FBS under the atmosphere of 5% CO 2 ‐95% air. Ginger extracts were found to enhance the adipocyte differentiation. Active constituent was purified and identified as gingerol. In the gingerol‐treated cells, insulin‐sensitive glucose uptake was increased. It is expected that ginger enhance the insulin‐sensitivity, and improve chronic disease, such as diabetes.