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Effect of high phosphorus diet on phosphorus metabolism in parathyroidectomized rats
Author(s) -
Katsumata ShinIchi,
Masuyama Ritsuko,
Koshihara Moyuru,
Matsuzaki Hiroshi,
Uehara Mariko,
Suzuki Kazuharu
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520220106
Subject(s) - endocrinology , medicine , parathyroid hormone , chemistry , bone resorption , kidney , excretion , resorption , phosphorus , receptor , calcium , organic chemistry
To determine the parathyroid hormone (PTH) action on kidney and bone by high phosphorus (P) diet, this study investigated PTH/PTH‐related peptide (PTHrP) receptor mRNA expression in 6‐week‐old parathyroidectomized (PTX) rats received constant amount of PTH. To maintain serum PTH levels equally to sham operated rats, PTX rats were constantly exposed to rPTH (1–34) and fed a control diet (0.3% P) and a high P diet (1.2% P) for 7 days, respectively. There were no significant differences in serum PTH (1–34) concentration in rats fed the control diet. In sham groups, serum PTH concentrations, both (1–84) and (1–34) fragments, were increased in rats fed the high P diet than in rats fed the control diet. Urinary excretions of P and C‐terminal telopeptides of type I collagen were significantly increased in both PTX and sham rats by the high P diet. PTH/PTHrP receptor mRNA expression in kidney and femur was not changed in both PTX and sham rats by the high P diet. In conclusion, high P diet did not change PTH action in PTX rats and increased urinary excretion of P and bone resorption regardless of PTH action.